| Latest Forum Topics / Riverstone Last:0.885 -- |
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RIVERSTONE HOLDINGS LIMITED
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Charity88
Senior |
01-Dec-2021 19:42
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https://www.ndtv.com/world-news/omicron-poses-very-high-risk-who-urges-countries-to-prep-10-points-2629169 Omicron Risk " Very High" , WHO Warns Of " Severe Consequences" : 10 Points
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Sgvale
Supreme |
01-Dec-2021 19:39
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Why all masks & gloves fell.? They are in fact ineffective in dealing w Omicron ? But still effective w Delta . | ||||
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vix787
Member |
01-Dec-2021 19:28
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If that's the case mean u just consolidate info from them and make a investing decision based on that on your own. No one to blame I guess
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JessTrang
Veteran |
01-Dec-2021 19:26
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WASHINGTON (NYTIMES) - An expert committee on Tuesday (Nov 30) voted to recommend that the Food and Drug Administration (FDA) authorise a Covid-19 pill from Merck for high-risk adults, the first in a new class of antiviral drugs that could work against a wide range of variants, including Omicron. The drug, known as molnupiravir, has been shown to  modestly reduce the risk of hospitalisation and death, predominantly from the Delta, Mu and Gamma variants. The expert panel recommended it for Covid-19 patients who are older or have medical conditions that make them vulnerable to severe illness. The pill could be authorised in the United States within days, and made available by year' s end.  
 
In the coming weeks, the FDA may also greenlight a similar pill from Pfizer that  appears to be significantly more effective than Merck' s. Health officials around the world have been counting on the new pills to reduce the number of severe cases and save lives. If Omicron causes a surge in severe infections, it could make them even more important. Scientists have yet to run experiments to see how well the pills block Omicron viruses from replicating. But there are reasons to think they would remain effective even if the variant can sometimes evade vaccines. Omicron has more than 30 mutations on the so-called spike protein that latches on to human cells. Some of those mutations may make it hard for vaccine-produced antibodies to attack the virus. But the pills do not target the spike protein. Instead, they weaken two proteins involved in the virus' replication machinery. Omicron carries only one mutation in each of those proteins, and neither looks as if it would stop the pills from doing their jobs. In a presentation to the committee members, Dr Daria Hazuda, a Merck executive, said molnupiravir' s activity is similar across known variants and that the drug works in a way that makes it likely to be active against new variants.  
 
Another Merck executive, Dr Nicholas Kartsonis, told the panel on Tuesday that the company is " feverishly working" to collect samples from people infected with Omicron that it can use in laboratory studies to help determine whether the drug will work against the variant. Virus cases are rising in many US regions, notably the Upper Midwest and Northeast. Nationwide, cases have increased since the start of November, prompting fears about a winter surge fuelled by Omicron, indoor holiday gatherings and the refusal of tens of millions to be vaccinated. In a clinical trial, molnupiravir was found to reduce by 30 per cent the risk of hospitalisation or death when given to high-risk, unvaccinated volunteers within five days after they started showing symptoms. It appears to be substantially less effective than Pfizer' s pill, which was found to lower risk by 89 per cent, and monoclonal antibody treatments, which have been found to cut it by at least 70 per cent. If molnupiravir is authorised, US supply is expected to be limited at first, though it will be more abundant than Pfizer' s pill. The Biden administration has ordered enough courses of treatment, at about US$700 (S$955) per person, for 3.1 million people. Merck is expected to supply those pills before February. The treatment is given within five days of the start of symptoms and is taken as 40 pills over five days. To get the pills, people will likely need to test positive for the virus soon after they start showing symptoms. But it often takes several days to get results from a polymerase chain reaction test, and in some parts of the country, it is difficult to find rapid tests that return results within 15 minutes. The FDA panel discussed safety concerns raised by some scientists about Merck' s pill. The treatment works by inserting errors into the virus' genes. Some scientists say there is a theoretical risk that it could trigger mutations in cells as well, potentially causing reproductive harm or a long-term risk of cancer. Representatives from Merck and from the FDA reviewed the results of safety studies in cells, animals  and clinical trials. " The overall risk of mutagenicity in humans is considered low," Dr Aimee Hodowanec, a senior medical officer at the FDA, said at the meeting, referring to the potential for the drug to induce mutations in the DNA of people taking it. Children and pregnant women were excluded from the clinical trials of the drug. Dr Kartsonis said that the company would start a pregnancy surveillance programme to monitor the outcomes of women exposed to molnupiravir during pregnancy, either inadvertently or intentionally. Britain,  which authorised Merck' s pill earlier in November, recommended that it not be given to pregnant or breastfeeding women, and that women who could become pregnant use contraception while taking the drug and for four days after. In a discussion about whether the pills should ever be given to pregnant women, committee members said they were struggling to weigh whether the potential risk of the drug during pregnancy was too high, given uncertain benefits. " The efficacy of this product is not overwhelmingly good," said Dr David Hardy, an infectious disease physician at Charles Drew University School of Medicine and Science in Los Angeles. " I think we really have to be careful about saying that this is the way to go." But several panel members said that in certain cases, the pills might be appropriate during pregnancy, such as if a woman has many medical conditions or when antibody treatments are not available. " I' m not sure you can ethically tell a pregnant woman who has Covid-19 that she can' t have the drug if she decided that' s what she needs," said Dr Janet Cragan, a paediatrician with the Centres for Disease Control and Prevention. |
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JessTrang
Veteran |
01-Dec-2021 19:23
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FRANKFURT (REUTERS) - BioNTech and Pfizer' s Covid-19 vaccine will likely offer strong protection against any severe disease from the new Omicron variant, BioNTech' s  chief executive told Reuters, as the firm weighs the need to  upgrade its commonly used shot. Lab tests are under way for the next two weeks to analyse the blood of people who had two or three doses of BioNTech' s Comirnaty vaccine to see if antibodies found in their  blood can inactivate Omicron, shedding light on whether new vaccines are needed. " We think it' s likely that people will have substantial protection against severe disease caused by Omicron," said BioNTech CEO and co-founder Ugur Sahin. He specified severe disease as requiring hospital or intensive care.  
 
Dr Sahin added he expects the lab tests to show some loss of vaccine protection against mild and moderate disease due to Omicron, but the extent of that loss was hard to predict. The biotech firm is speedily working on an upgraded version of its vaccine, of which well over two billion doses have been delivered, although it remains unclear whether that is needed, he added. Dr Sahin said getting a third vaccine shot, known as a booster, will likely confer a layer of protection against Omicron infections of any severity, compared with those with just a two-shot course. " To my mind, there' s no reason to be particularly worried. The only thing that worries me at the moment is the fact that there are people who have not been vaccinated at all," he added. BioNTech' s guarded confidence contrasts with a sense of alarm conveyed by the chief executive of rival vaccine maker Moderna, Mr Stephane Bancel, who has raised the prospect of  a material drop in protection against the new coronavirus lineage  from current vaccines. Dr Sahin said antibodies brought about by vaccination could struggle to latch on to the new virus lineage, but he added that T-cells, another line of immune defence, were set to recognise the vast parts of Omicron' s spike protein that remain  unchanged.   While antibodies bind to viruses directly and prevent infections, longer lasting T-cells attack cells that have already been hijacked by the virus, warding off viral replication and severe disease. Pfizer and BioNTech have already created versions of their established mRNA-based vaccine - based on the original virus found in China - to target the so-called Alpha and Delta variants, with clinical trials continuing. Those efforts are not meant to yield commercial products but to establish a routine with regulators that will help speed up any future vaccine relaunch. Dr Sahin said that was why regulators would unlikely require testing on human volunteers and an analysis of their immune reaction for any Omicron-specific vaccine upgrade. " The advantage is that we have been practising this pit stop for months, and if we change tyres for real, we will be able to say we' ve demonstrated this before for one variant and for two variants," Dr Sahin said. He said he still expects that a market launch with an initial batch of 25 to 50 million doses would take about 100 days, provided regulators are satisfied. He would not be drawn on whether Omicron will become as dominant as the Delta variant. " But even if so, that in itself is no reason to panic," he said. The European Union drug regulator said on Tuesday that it could  approve vaccines adapted to target Omicron within three to four months  if needed, but that existing shots would continue to provide protection. |
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ttbanthony
Veteran |
01-Dec-2021 19:19
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Wait and see.
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sutiono
Veteran |
01-Dec-2021 19:11
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Looked like SA wanted to play down the seriousness of Omicron becos many countries cancelled flights with them.
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Godwinlow
Elite |
01-Dec-2021 18:58
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The African doctor already said mild already le
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ttbanthony
Veteran |
01-Dec-2021 18:36
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I am suspecting Omicron is deadlier than Delta.
Fatality case stubbornly high https://www.channelnewsasia.com/world/germany-reports-highest-daily-covid-19-death-toll-9-months-2350436
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JessTrang
Veteran |
01-Dec-2021 18:26
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Bro, good luck. Your avg price should be @$1 but recent surge did not even touch $0.85. take profit and reduce loss first for this numbers of shares you bought @0.695 in the future unless you have confidence in the company and vested for your hindsight.
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TA_Expert
Supreme |
01-Dec-2021 18:21
Yells: "The World has changed" |
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Why not? Thier conviction sometimes proved a strong case.
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JessTrang
Veteran |
01-Dec-2021 18:17
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Bro, your comments made me LOL... Sound like all forumers ownself talk ownself song.. 🤣 🤣
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ttbanthony
Veteran |
01-Dec-2021 18:01
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Wow. 1.33
Super high.
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FreedomAngelz
Veteran |
01-Dec-2021 17:57
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added some shares at 0.695 for averaging down....(last purchase $1.33) | ||||
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vix787
Member |
01-Dec-2021 17:51
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Err.... Looking at your userid I thought u not prone to look for advise in a forum?
Forum comment can be very biased.... Seriously u listen?
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TA_Expert
Supreme |
01-Dec-2021 17:43
Yells: "The World has changed" |
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I lost money after listening to those experts of RS to buy. wavehunter was right afterall. |
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Richardlai
Master |
01-Dec-2021 16:45
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Haha .... this gem is going for a song !
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vix787
Member |
01-Dec-2021 16:25
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High volume but price sort of maintain. Looks like someone absorbing all the short term trader sell at current price.
Expect another push soon..... This few days? |
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ttbanthony
Veteran |
01-Dec-2021 16:16
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RS already vaccinated against all variants.
Immuned against all good news.
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vix787
Member |
01-Dec-2021 16:14
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Glove shld thrive this time. Look at the way countries react. If not serious usually countries will take a wait n see attitude before anything concrete. Becos border restriction really hurt a country economy and all want to push to reopen.
All the countries react as if they receive more data than the public shld know. Death case will surface once the spread become rapid. It maybe mild but once this new. Variant cripple the healthcare system, mild case will cause death too. |
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